Marianne Boesky Gallery was established in 1996 in Soho, New York City. Since its inception, the Gallery's mission has been to represent and support the work of emerging, mid-career, and established international artists of all media. The gallery moved to its flagship space in Chelsea in 2005; in concert with this move, the gallery added several critically recognized emerging artists to its roster such as Jay Heikes, Adam Helms, Anthony Pearson, Diana Al-Hadid, and William J. O'brien. The gallery also continued to expand its program internationally, adding Pier Paolo Calzolari in 2011, and more recently adding South African artist Serge Alain Nitegeka and Brazilian artist Thiago Rocha Pitta. In April 2014, the gallery became the worldwide representative of Frank Stella.
Currently, the gallery has a second location, Boesky East, which opened in September 2014, showcases gallery artists and projects in the more cutting edge context of New York City's lower east side.